CEN64 aims to accurately emulate the N64 (like MESS), but it requires a high-end computer to run games at full speed.It is still in active development, currently being rewritten for the third time for the upcoming Apple Silicon. Sixtyforce is Mac-only, closed-source, which asks you to pay for it to use all its features.Its core is also very unstable and prone to crashing. MESS uses a very accurate method of emulation, but as a result is very, very slow, so it's hardly usable on most current hardware.N64 emulation on Wii is not very good, and it is recommended to stick with the Virtual Console N64 releases. Not64 claims to be better optimised, as well as having higher compatibility and more frequent updates. Wii64 and Not64 are both based on Mupen64, with Not64 being a fork of Wii64.It's the only option for N64 emulation on PSP. On PSP, most games are unplayable, but there's a small amount of them that work really well with the right settings (California Speed, Donkey Kong 64, and Quest 64, for example). Daedalus, results are even more hit-and-miss than on other emulators due to being made for PSP first and foremost.Bizhawk lacks portability however, and is only Windows and OSX only. Bizhawk has a port of M64+ and it seems to work well enough.RetroArch has a port of M64+ it has support for multi-pass shaders.There are GUIs made for it, but many are problematic and glitchy. It lacks a native GUI, and instead is ran by dragging and dropping ROMS and editing the config with notepad++. Mupen64+ is the best overall N64 emulator, but you still need PJ64 for certain games.Mupen64Plus is receiving far more updates, and will likely be the go-to emulator for general use in the future. Mupen64Plus improves upon Mupen64 even further, while Project64 2.1 only fixed a few things and broke others.

In terms of compatibility with the N64's game library, vanilla Mupen64 was basically always better than Project64 1.6, with 1964 basically only working well for a few different games.

Refer to this link for optimal emulator settings based on the game you want to play. Every emulator has its own unique compatibility issues, and it varies significantly even within one emulator if using different plugins. N64 emulation is a complete mess (and broken).

Best n64 emulator for wii